Cell Therapy

Cell therapy is a relatively new discipline within the medical sciences. It uses intact cells, either human or microbial, to provide various benefits to the patient.

Cell therapies and regenerative medicine are two distinct, but overlapping, innovative disciplines in medicine. Not all regenerative medicine techniques involve the use of intact cells and not all cell therapies are regenerative in nature.

There are two main disciplines within cell therapy. One aims to achieve the integration of cells at the site of injury, thereby replacing damaged tissue, whereas the other uses cells to release certain therapeutic factors to induce self-healing, often in combination with manipulation of the patient’s own microbial community.

CELL THERAPY

Uses intact, living, whole cells
Cells can actively migrate to where needed
Cells can continuously produce compounds
Can control cells’ activity,
replication and death

CONVENTIONAL PHARMACEUTICALS

Uses specific compound(s)
Compounds rely on body’s circulatory system
Dose needs to be controlled by intake
Little control over duration of activity —
Reliant on body’s elimination system

The advantage of using intact, living cells is that they can secrete a variety of compounds, sense and respond to a range of signals and migrate to specific areas within the body or tissue. Furthermore, the activity, replication and death of living cells can be tightly controlled by a variety of methods, with the result that they are not solely reliant on the patient’s own metabolic and elimination processes, or genetic makeup.


These factors place them in a unique position to meet a range of critical unmet needs that more traditional pharmaceutical methods cannot. Such techniques have already showed promise for the treatment of cancers, infections, autoimmune and metabolic diseases, as well as tissue repair and regeneration¹.

The liver’s unparalleled regenerative ability makes it an excellent candidate for new potential regenerative medicine-based cell therapies. Promethera® Biosciences have already shown that mature hepatocyte transplantation can successfully improve liver function².

Mature hepatocytes, however, are difficult to produce and their cryo-preservation can be problematic. Therefore, Promethera® Biosciences is currently focused on developing an off-the-shelf technology with greater ease of manufacturing. Adult-derived liver progenitor cells cultured in vitro and then engrafted into livers have shown very promising results. These also have the potential to be used for pharmacotoxicology screening of new drugs and optimization of new compounds³.


Now that these products are involved in clinical trials for various liver diseases, Promethera® Biosciences has positioned itself as a global leader in cell therapy and regenerative medicine for the treatment of inborn and acquired liver diseases that have no effective therapeutic cure.

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References:

  1. Fischbach MA, Bluestone JA, Lim WA. Cell-Based Therapeutics: The Next Pillar of Medicine. Sci Transl Med. 2013;5:3005568
  2. Sokal EM. Regeneration of the Liver: From Hepatocyte Cells to Deficient Hepatic Cells. Bull Mem Acad R Med Belg. 2009;164:207-212.
  3. Najimi M, et al. Adult-Derived Human Liver Mesenchymal-Like Cells as a Potential Progenitor Reservoir of Hepatocytes? Cell Transplantation. 2007;16:717-728.